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Pyruvate Kinase Deficiency in Dogs

Dog being treated for red blood deficiency


This disease is caused by a lack of pyruvate kinase, which is a red blood cell enzyme that helps convert glucose into energy when oxygen levels drop. This can lead to red blood cells dying quicker than usual. The cells build up sodium, become swelled and eventually burst. Red blood cells that do not burst can become defective and are eventually destroyed by the liver.


The most common sign of Pyruvate Kinase Deficiency deficiency is a lack of energy and an unwillingness to exercise.


The only known treatment is a bone marrow transplant.

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