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Copper Storage Disease in Dogs

Pictured: Dog getting treated for Copper Storage Disease



Copper Storage Disease, also known as Hepatotoxicosis, is a genetic liver disease caused by an accumulation of copper in the liver. Copper is found in all foods and is absorbed by the intestines, stored in the liver and excreted through the bile system.

Some dog breeds are genetically unable to eliminate copper from the liver. Some symptoms of copper storage disease include:

  • Weight loss
  • Anorexia
  • Depression
  • Vomiting
  • Weakness
  • Lethargy
  • Dehydration
  • Bloody stool


Treatments include IV fluids, lactulose, d-penicillamine for binding the copper, and zinc acetate given before feeding. Vitamin C may also help reduce the absorption of copper.



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