GME in Dogs


Granulomatous Meningoencephalitis (GME) is also known as Pug Dog Encephalitis (PDE). GME is an inflammatory disease of the central nervous system. There are three types of GME:

  • Local – limited to one location in the nervous system
  • Disseminated – involves many locations in the nervous system
  • Ophthalmic – involving the optic nerve in the eye

A dog may suffer from more than one type of GME. The disseminated form is the most common. Focal GME typically has a slower onset and disseminated is more rapid.


Medications and radiation therapy can decrease symptoms but unfortunately most dogs with GME / PDE will eventually die from the disease. Medications and radiation therapy for dogs can cost thousands of dollars.

Cost to Treat: $6,000 to $7,000


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